Van de Ven Double Halts Everton's Run at Brand New Home Ground
Micky van de Ven became the initial backline player to score twice in a English top-flight game for Spurs since the Belgian defender in March 2013.
Match summary
Micky Van de Ven nods into the net twice in first half
The home side's Jake O'Brien has equalizer ruled after VAR review
Pape Matar Sarr nets third in dying moments
This loss is the Merseyside club's initial at their new ground
The Tottenham defender scored twice as Tottenham extended their unbeaten run on the road in the top division and delivered Everton their initial loss at Hill Dickinson Stadium.
Everton were undefeated in their last five matches at their new ground at the dockside location, having left Goodison Park behind after 133 years at the end of last season.
But Spurs captain the Dutchman struck twice from set-pieces in the first half to place their impressive record at risk, and they were unable to turn it around before Pape Matar Sarr - assisted by ex-Everton forward Richarlison - nodded in a third to seal the victory.
The Everton defender believed he had equalized the scores five minutes after Van de Ven's opener, glancing a bullet header past Guglielmo Vicario from an Everton corner.
Beto, in the meantime, missed a handful of opportunities, while the Italian goalkeeper made a succession of excellent stops to ensure Tottenham went five away games unbeaten in the English top flight.
But the video assistant referee stepped in, advising Craig Pawson to check the score on the screen and the official ruled that Jack Grealish and the attacker were in an illegal position and had impeded with the Tottenham goalkeeper.
The win elevates Thomas Frank's side into third place in the Premier League, five points off north London rivals and leaders Arsenal.
Everton remain in 14th position and are half a dozen points ahead of the relegation zone.
Spurs breakdown: The defender excels in role at both ends of pitch
After a uninspiring midweek display in the European competition against the French side, where they mustered a only attempts on goal, Frank opted for the French striker in attack instead of former Toffees player Richarlison.
The new arrival was unable to influence the game before being substituted for the substitute after an hour on the pitch, but it emerged he proved unnecessary in the end.
Defender the Dutchman transformed into an offensive threat to be feared.
Tottenham's opening strike came from a well-worked corner routine, with the midfielder directing the ball back across the face of goal for an unmarked Van de Ven to head home.
And the captain - filling in as captain in Cristian Romero's unavailability - notched his second in added time as he outjumped the England keeper to nod in.
Van de Ven was just as impressive in defensive duties, partnering effectively with Kevin Danso as the pair handled superbly with the 34 crosses sent their way by Everton.
Everton analysis: Everton missing striker's instinct
The club's new home had been a happy hunting ground, but it appears the novelty may have faded somewhat and supporters flocked to the gates after the midfielder's final goal for Tottenham.
The break in the team's winning streak at home won't be a major concern for the manager, but their striker situation are.
Beto and Thierno Barry - the Everton's two recognised centre-forwards - had netted only one league goal between them before the weekend's match.
And they were failed to add to that poor record on a wet and gloomy night on in Liverpool.
The striker's form was summed up when he opted to overhead kick a clear chance from near the goal, despite having space and opportunity to readjust for a simpler shot that would have tested Vicario.
Barry, as well, failed to make an impact after coming on for the starter in the 65th minute.
It was not for a shortage of opportunity. The majority of the home side's offensive moves came through the winger and Ndiaye, who tirelessly whipped threatening balls into the Tottenham box.
Upcoming fixtures for both teams?
The Toffees: The team head to the Stadium of Light in the top flight on Monday, 3 November at 20:00 GMT.
Tottenham: The London club travel to Newcastle's ground on Wednesday, 29 October for their next round League Cup match against Newcastle.